Glucose Affects the Quality and Properties of Hard Tissue in Diabetes Mellitus Model

Patients with diabetes mellitus (DM) are at an increased risk of tooth loss compared to healthy individuals. Although studies human subjects suggest that control is affected by periodontitis, there scarce mechanistic evidence supporting its biological plausibility. Therefore, using type 2 DM rat bone marrow mesenchymal stromal cells (BMMSCs) were incubated four concentrations glucose (5.5, 8.0, 12.0 or 24.0 mM), the effects different on BMMSCs stemness and osteogenesis evaluated. High decreased fluorescence intensity β-actin, STRO-1, CD73 CD90. Moreover, cell proliferation high concentrations. Alkaline phosphatase activity was mM mM. In contrast, osteocalcin production calcium deposition considerably Differences in calcium/phosphate ratio associated various similar deposition. The mRNA expression Runx2 inflammatory cytokines increasing concentration. RANKL/OPG A concentration hard tissue formation, but quality mineralized decreased. Thus, had a resorption case uncontrolled even if periodontal treatment stabilized state periodontitis for moment.